Evidence supporting the use of: Brassica
For the body system: Estrogen

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Table of Contents

Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Brassica vegetables, which include broccoli, Brussels sprouts, cabbage, cauliflower, and kale, have been studied for their effects on estrogen metabolism. The primary scientific interest revolves around their high content of glucosinolates, which are precursors to compounds like indole-3-carbinol (I3C) and diindolylmethane (DIM). These compounds have been shown in both animal and human studies to influence estrogen metabolism by promoting the conversion of estrogen into less potent forms, potentially lowering the risk of estrogen-related conditions such as certain breast cancers.

Several clinical trials and epidemiological studies suggest that higher intake of Brassica vegetables is associated with beneficial changes in estrogen metabolism, such as increased production of 2-hydroxyestrone relative to 16α-hydroxyestrone. These shifts are considered favorable because the 2-hydroxy metabolite is less estrogenic and possibly protective against hormone-dependent cancers. However, while laboratory and animal studies are robust, human evidence, though promising, is moderate and sometimes inconsistent, often due to variability in study design or population differences.

Overall, the use of Brassica for supporting the estrogen body system is justified by scientific evidence, but the strength of this evidence is moderate rather than conclusive. Further well-controlled human trials are needed to fully clarify the extent and mechanisms of these effects.

More about Brassica
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