Evidence supporting the use of: Brassica (unspecified)
For the body system: Estrogen

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Table of Contents

Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Brassica refers to a genus of plants including broccoli, cauliflower, cabbage, kale, and Brussels sprouts. These vegetables are often used to support the estrogen body system, particularly for their potential roles in estrogen metabolism. Scientific evidence suggests that compounds found in Brassica vegetables, especially glucosinolates and their breakdown products like indole-3-carbinol (I3C) and diindolylmethane (DIM), can influence estrogen metabolism in the liver. These compounds may promote the formation of less potent estrogen metabolites, which are thought to be less likely to promote hormone-dependent cancers. Several clinical studies have shown that consumption of Brassica vegetables or supplementation with I3C/DIM can shift estrogen metabolism towards a more favorable profile, though the clinical significance of these changes is still under investigation. The American Institute for Cancer Research and other scientific bodies acknowledge a potential protective effect of Brassica vegetable consumption against certain hormone-related cancers, based on epidemiological and mechanistic studies. However, while the evidence is promising, it is not unequivocal, and more robust human clinical trials are needed to fully substantiate the health claims. Overall, the use of Brassica to support estrogen metabolism is supported by a moderate level of scientific evidence, reflected in a rating of 3 out of 5.

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