Evidence supporting the use of: Cholesterol
For the body system: Estrogen

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Table of Contents

Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Cholesterol is scientifically validated as a critical precursor in the biosynthesis of steroid hormones, including all estrogens. In human physiology, all steroid hormones—such as estrogen, progesterone, and testosterone—are synthesized from cholesterol through a well-characterized series of enzymatic reactions in the gonads and adrenal glands. Cholesterol is converted first to pregnenolone, which is then further processed to produce progesterone and subsequently estrogens (estradiol, estrone, and estriol). Multiple peer-reviewed studies and biochemistry textbooks confirm that without adequate cholesterol, estrogen synthesis is impaired (Guyton and Hall Textbook of Medical Physiology, 14th Edition; Payne & Hales, 2004, Endocrine Reviews).

Clinically, extremely low cholesterol levels (e.g., due to genetic disorders or aggressive lipid-lowering therapy) have been associated with disrupted menstrual cycles and decreased estrogen production. Conversely, normal physiological levels of cholesterol are essential for proper hormonal function. However, this does not mean dietary cholesterol supplementation is required for most people, as the body synthesizes sufficient cholesterol for hormone production in healthy individuals. In summary, cholesterol’s crucial role in supporting the estrogen body system is an established scientific fact, though this pertains to its function as a substrate for hormone synthesis rather than a direct supplement for increasing estrogen.

More about Cholesterol
More about Estrogen

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