Evidence supporting the use of: Daidzein
For the body system: Estrogen

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Table of Contents

Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Daidzein is an isoflavone found predominantly in soybeans and other legumes. It is classified as a phytoestrogen due to its structural similarity to human estrogen, allowing it to weakly bind to estrogen receptors in the body. Scientific interest in daidzein stems from its potential to modulate estrogenic activity, particularly in populations experiencing hormonal changes, such as postmenopausal women.

Several clinical trials and meta-analyses have investigated the effects of daidzein and other soy isoflavones on menopausal symptoms, bone health, and cardiovascular risk factors. Some studies report modest benefits for hot flashes, while others show little to no effect. The variability in results is thought to be influenced by individual differences in gut microbiota, which affects daidzein metabolism (notably the conversion to equol, a more potent estrogenic metabolite in some people).

Overall, the evidence supports a potential, but modest, estrogenic effect of daidzein, especially in individuals who can metabolize it efficiently. However, its activity is much weaker than endogenous estrogen, and findings are not universally consistent. The use of daidzein as a support for the estrogen body system is therefore grounded in scientific study, though with moderate strength of evidence and some limitations.

More about daidzein
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