Evidence supporting the use of: Diindolylymethane
For the body system: Estrogen

Links: Go back one page, Tool main page, Ingredients list, Health conditions list, Body systems list

Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Diindolylmethane (DIM) is a compound formed during the digestion of indole-3-carbinol, which is found in cruciferous vegetables such as broccoli, Brussels sprouts, and cabbage. DIM has attracted scientific interest due to its effects on estrogen metabolism. Laboratory and preliminary clinical studies suggest that DIM can favorably modulate estrogen metabolism by promoting the conversion of estrogen into less potent forms, such as 2-hydroxyestrone, which are thought to be less likely to stimulate estrogen-sensitive tissues. This has led to hypotheses that DIM may support hormone balance, particularly in conditions associated with estrogen dominance, such as premenstrual syndrome (PMS) or menopausal symptoms.

However, while preclinical (animal and cell culture) and a few small human studies have demonstrated that DIM can alter estrogen metabolism, robust clinical trials demonstrating clear health benefits or symptom relief in humans are lacking. Most evidence is preliminary, and the impact on clinical endpoints, such as breast cancer risk reduction or significant improvement in estrogen-related symptoms, has not been firmly established. Thus, while there is a scientific rationale and some supporting data, the overall level of evidence is moderate to low, and further research is needed to substantiate routine use of DIM for "supporting the estrogen body system."

More about Diindolylymethane
More about Estrogen

Products containing Diindolylymethane

We currently have no products on Vitabase that contain this ingredient.