Evidence supporting the use of: Diindoylmethane
For the body system: Estrogen

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Diindolylmethane (DIM) is a compound formed in the body during the digestion of indole-3-carbinol, which is found in cruciferous vegetables like broccoli and Brussels sprouts. DIM has been studied for its effects on estrogen metabolism. Scientific research shows that DIM can influence the balance of estrogen metabolites, potentially favoring the production of less potent and less harmful forms of estrogen. These effects have been observed in laboratory and animal studies, as well as in a limited number of human clinical trials. For example, some research suggests that DIM supplementation may shift estrogen metabolism toward increased 2-hydroxyestrone (a weaker estrogen metabolite) and decreased 16-alpha-hydroxyestrone (a more potent metabolite), which is considered beneficial in certain contexts.

However, while the mechanistic data and small-scale clinical studies are promising, there is insufficient large, high-quality clinical trial evidence to conclusively demonstrate that DIM supplementation provides concrete health benefits related to estrogen balance in the general population. Most studies to date have focused on biomarkers rather than clinical outcomes. As such, the evidence is rated moderate (3 out of 5): there is scientific plausibility and supportive early data, but more robust research is needed to fully validate its efficacy for supporting the estrogen system in humans.

More about Diindoylmethane
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