Evidence supporting the use of: Flax
For the body system: Estrogen
Synopsis
Source of validity: Scientific
Rating (out of 5): 4
Flax (Linum usitatissimum) is scientifically supported as a dietary source that can impact the estrogen body system, primarily due to its high content of lignans. Lignans are a type of phytoestrogen—plant compounds that can exert weak estrogenic or anti-estrogenic effects in the body. Multiple clinical and preclinical studies have shown that flaxseed lignans, particularly secoisolariciresinol diglucoside (SDG), are converted by intestinal bacteria into enterolignans (enterodiol and enterolactone), which can bind to estrogen receptors and modulate estrogen activity.
Research indicates that flaxseed consumption can influence estrogen metabolism, often increasing the production of less potent estrogen metabolites. Some randomized controlled trials have found that flaxseed supplementation can reduce breast cancer risk markers, such as cell proliferation in breast tissue, especially among postmenopausal women. Flaxseed has also been shown to help manage menopausal symptoms and may modestly impact menstrual cycle regularity and hormone levels in premenopausal women.
While more research is needed to clarify the long-term effects and establish optimal dosages, the evidence supporting flaxseed’s role in modulating estrogenic activity is robust and recognized in the scientific literature. Thus, flaxseed is considered scientifically validated for supporting the estrogen body system.
Other ingredients that support Estrogen
7-hydroxymatairesinol (HMR)black cohosh
chaste tree
d-glucarate
daidzin
dandelion
DHEA (dehydroepiandrosterone)
DIM (diindolylmethane)
dong quai root
fennel
flaxseed
genistein
genistin
ginseng
HMR lignan
hops
indole-3-carbinol
licorice root
lignans
maca
sage
secoisolariciresinol diglucoside
soybean
spearmint leaf
vitamin B6
vitamin E
wild yam
red clover
anise
yarrow
dioscorea
Equol (proprietary)
soy isoflavones
27-deoxyactein
4-Hydroxyandrostenedione
8-Prenylnaringenin
Agnuside
Anti-aromatase
Brassica
Bugbane
biochanin
Barbasco
Cohosh
Clary sage
Cruciferous
Casticin
Coumesterol
DHEA
Daidzein
Dong Quai
Diosgenin
Isoflavones
Soy Protein