Evidence supporting the use of: Formononetin
For the body system: Estrogen

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Formononetin is a naturally occurring isoflavone found in various plants, including red clover (Trifolium pratense). It is classified as a phytoestrogen, meaning it can exert estrogen-like effects in the body by binding to estrogen receptors, albeit with less potency than endogenous estrogens. The use of formononetin for supporting the estrogen system is based on its structural similarity to estrogen and its presence in traditional herbal remedies for menopausal symptoms.

Scientific studies, primarily in vitro and animal models, have demonstrated that formononetin can activate estrogen receptors (ERα and ERβ) and influence estrogen-responsive gene expression. Some research reports suggest potential benefits of formononetin in alleviating menopausal symptoms, promoting bone health, and modulating lipid metabolism. However, the majority of clinical evidence is derived from studies using whole extracts of red clover or soy, which contain a mixture of isoflavones, rather than isolated formononetin. Controlled human trials specifically examining formononetin’s effects on the estrogen system are limited and often inconclusive.

In summary, there is scientific plausibility and limited experimental evidence supporting formononetin’s role as a phytoestrogen. However, direct clinical validation for its efficacy in supporting the estrogen body system is weak, and the overall evidence quality is low. Additional well-designed human studies are needed to establish its safety and effectiveness for this purpose.

More about formononetin
More about Estrogen

Other body systems supported by formononetin

Estrogen
Female Reproductive System
Heart
Ovaries
Reproductive System

Products containing formononetin

We currently have no products on Vitabase that contain this ingredient.