Genistin is an isoflavone glycoside predominantly found in soybeans and other legumes. It is a phytoestrogen, meaning it is a plant-derived compound with a chemical structure similar to that of human estrogen. Upon ingestion, genistin is converted in the gut to its aglycone form, genistein, which has been more extensively studied for its estrogenic effects. Scientific research suggests that genistin and genistein can bind to estrogen receptors, particularly estrogen receptor beta, and exert weak estrogen-like activity in the body.

Several clinical and preclinical studies have investigated the potential benefits of soy isoflavones for menopausal symptoms and bone health, both of which are related to estrogen function. Meta-analyses indicate that soy isoflavones may help alleviate mild menopausal symptoms such as hot flashes, though the magnitude of effect is generally modest. There is also some evidence for beneficial effects on bone mineral density in postmenopausal women. However, most evidence comes from studies of mixed isoflavones (not isolated genistin), and the clinical impact of genistin specifically is less clear.

In summary, there is scientific rationale and preliminary evidence for the use of genistin-containing foods or supplements to support estrogen-related body systems, but the evidence is moderate and not definitive. More high-quality, targeted research is needed to fully establish the efficacy of genistin itself.