Evidence supporting the use of: Glabridin
For the body system: Estrogen

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Table of Contents

Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Glabridin is a flavonoid compound found in licorice root (Glycyrrhiza glabra). There is some scientific interest in glabridin for its potential effects on the estrogen system. Laboratory and animal studies have shown that glabridin can act as a phytoestrogen, meaning it can bind to estrogen receptors and mimic some of the effects of endogenous estrogens. For example, research has demonstrated that glabridin can activate estrogen receptor-mediated gene expression in vitro and produce estrogen-like effects in animal models, such as promoting bone density and influencing lipid metabolism. However, there is a lack of robust human clinical trials confirming these effects or supporting the use of glabridin supplements for managing estrogen-related conditions in people. The evidence base is therefore limited, and glabridin is not widely used in mainstream medicine for estrogen modulation. Historically, licorice root has been used in traditional medicine systems for various health concerns, but its application specifically for estrogen support is more recent and based on emerging scientific data rather than longstanding traditional use. In summary, there is preliminary scientific evidence, mostly from non-human studies, suggesting glabridin's activity as a phytoestrogen, but clinical relevance in humans remains uncertain.

More about Glabridin
More about Estrogen

Other body systems supported by Glabridin

Brain
Estrogen
Skin

Products containing Glabridin

We currently have no products on Vitabase that contain this ingredient.