Evidence supporting the use of: Hops
For the body system: Estrogen

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Hops (Humulus lupulus) has been traditionally used for its sedative and calming effects, but increasing scientific interest has focused on its potential estrogenic activity. The primary compound in hops responsible for these effects is 8-prenylnaringenin, a potent phytoestrogen. Several in vitro and animal studies have shown that 8-prenylnaringenin can bind to estrogen receptors and exert estrogen-like activity. Some small-scale human studies and clinical trials have explored the use of hops extracts for alleviating menopausal symptoms such as hot flashes and night sweats. While these studies suggest a possible benefit, results are mixed, and sample sizes are often limited. The European Medicines Agency and other herbal monographs acknowledge the traditional use of hops for menopausal complaints, but also note that robust clinical evidence is still emerging. Overall, there is moderate scientific support for the use of hops in supporting the estrogen body system, especially for symptom management in menopause. However, more large-scale, well-designed clinical trials are needed to confirm efficacy and safety.

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