Evidence supporting the use of: Isoflavones (mixed)
For the body system: Estrogen

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Table of Contents

Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Isoflavones, primarily derived from soy and red clover, are a class of phytoestrogens—plant-derived compounds with estrogen-like activity. Their use to support the estrogen body system is based on their structural similarity to estradiol, the primary female sex hormone. Numerous studies have explored the effects of isoflavones, particularly genistein and daidzein, in alleviating menopausal symptoms such as hot flashes, and in supporting bone health in postmenopausal women. Meta-analyses and randomized controlled trials suggest that isoflavones can modestly reduce the frequency and severity of hot flashes, although the effect size is variable and may not be clinically significant for all individuals. There is also evidence that isoflavones may exert beneficial effects on bone mineral density and cardiovascular markers, but findings are inconsistent, and long-term safety data are limited. In populations with high dietary intake of soy (e.g., East Asian countries), isoflavones are believed to contribute to lower rates of menopausal symptoms and some estrogen-related conditions, though cultural and dietary differences may confound these associations. The FDA and other regulatory agencies note that while isoflavones are generally recognized as safe, their estrogenic activity warrants caution in certain populations, such as women with estrogen-sensitive cancers. Overall, there is moderate scientific evidence supporting their use in supporting estrogen-related body systems, especially for menopausal symptom relief.

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Products containing Isoflavones (mixed)

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