Evidence supporting the use of: Soy
For the body system: Estrogen
Synopsis
Source of validity: Scientific
Rating (out of 5): 3
Soy (Glycine max) is used to support the estrogen body system primarily due to its content of isoflavones, which are phytoestrogens—plant-derived compounds structurally similar to human estrogen. These isoflavones, mainly genistein and daidzein, can bind to estrogen receptors and exert weak estrogenic or anti-estrogenic effects, depending on the hormonal environment. Several clinical studies have evaluated soy isoflavones for their potential to alleviate menopausal symptoms, such as hot flashes, which are linked to declining estrogen levels. Systematic reviews and meta-analyses suggest that soy isoflavones may provide modest relief from these symptoms, although results are variable and the effect size is generally small.
Beyond menopausal symptom relief, research also explores soy’s potential impact on bone health and cardiovascular risk, both of which are influenced by estrogen status. However, the evidence here is less consistent, with some studies noting slight benefits and others showing no significant effect. Overall, while soy is not a substitute for estrogen therapy, there is scientific support—though moderate in strength—for its use in supporting the estrogen system, particularly in the context of mild menopausal symptom management. Major health organizations recognize soy isoflavones as safe for most individuals, but their efficacy is not universally established. Thus, soy is used for estrogen support based on scientific evidence, though this evidence is not strong or conclusive.
Other ingredients that support Estrogen
7-hydroxymatairesinol (HMR)black cohosh
chaste tree
d-glucarate
daidzin
dandelion
DHEA (dehydroepiandrosterone)
DIM (diindolylmethane)
dong quai root
fennel
flaxseed
genistein
genistin
ginseng
HMR lignan
hops
indole-3-carbinol
licorice root
lignans
maca
sage
secoisolariciresinol diglucoside
soybean
spearmint leaf
vitamin B6
vitamin E
wild yam
red clover
anise
yarrow
dioscorea
Equol (proprietary)
soy isoflavones
27-deoxyactein
4-Hydroxyandrostenedione
8-Prenylnaringenin
Agnuside
Anti-aromatase
Brassica
Bugbane
biochanin
Barbasco
Cohosh
Clary sage
Cruciferous
Casticin
Coumesterol
DHEA
Daidzein
Dong Quai
Diosgenin
Isoflavones
Soy Protein