Evidence supporting the use of: Soy
For the body system: Estrogen
Synopsis
Source of validity: Scientific
Rating (out of 5): 3
Soy (Glycine max) is used to support the estrogen body system primarily due to its content of isoflavones, which are phytoestrogens—plant-derived compounds structurally similar to human estrogen. These isoflavones, mainly genistein and daidzein, can bind to estrogen receptors and exert weak estrogenic or anti-estrogenic effects, depending on the hormonal environment. Several clinical studies have evaluated soy isoflavones for their potential to alleviate menopausal symptoms, such as hot flashes, which are linked to declining estrogen levels. Systematic reviews and meta-analyses suggest that soy isoflavones may provide modest relief from these symptoms, although results are variable and the effect size is generally small.
Beyond menopausal symptom relief, research also explores soy’s potential impact on bone health and cardiovascular risk, both of which are influenced by estrogen status. However, the evidence here is less consistent, with some studies noting slight benefits and others showing no significant effect. Overall, while soy is not a substitute for estrogen therapy, there is scientific support—though moderate in strength—for its use in supporting the estrogen system, particularly in the context of mild menopausal symptom management. Major health organizations recognize soy isoflavones as safe for most individuals, but their efficacy is not universally established. Thus, soy is used for estrogen support based on scientific evidence, though this evidence is not strong or conclusive.
Other ingredients that support Estrogen
27-deoxyactein7-hydroxymatairesinol (HMR)
8-Prenylnaringenin
Agnuside
anise
anti-aromatase
barbasco
biochanin
black cohosh
Brassica
bugbane
casticin
chaste tree
Clary sage
cohosh
coumesterol
cruciferous
d-glucarate
daidzein
daidzin
dandelion
DHEA
DHEA (dehydroepiandrosterone)
DIM (diindolylmethane)
dioscorea
diosgenin
dong quai
dong quai root
equol (proprietary)
fennel
flaxseed
formononetin
genistein
genistin
ginseng
Ginsenosides
Glabridin
Glycetein
HMR lignan
hops
horny goat weed
hydroxymatairesinol
indole-3-carbinol
isoflavones
Labisia pumila
Lariciresinol
licorice root
lignans
maca
Miroestrol
Phytoestrogens
Puerain
red clover
sage
secoisolariciresinol diglucoside
Shataverins
Soy
soy isoflavones
Soy Protein
soybean
spearmint leaf
vitamin B6
vitamin E
Vitex Agnus-Castus
Wild yam
Yarrow
