Evidence supporting the use of: 1,3,7-Trimethylpurine-2,6-dione
For the health condition: Exercise

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Synopsis

Source of validity: Scientific
Rating (out of 5): 5

1,3,7-Trimethylpurine-2,6-dione is the chemical name for caffeine. Caffeine is widely recognized and scientifically validated as an ergogenic aid—that is, a substance that enhances physical performance. Numerous randomized controlled trials and meta-analyses have shown that caffeine supplementation can improve endurance, strength, power output, and perceived exertion during exercise. The mechanism is thought to involve both central and peripheral effects: caffeine acts as an adenosine receptor antagonist in the brain, reducing fatigue and increasing alertness, while it may also enhance calcium release in muscle cells, improving muscle contraction.

Scientific bodies such as the International Olympic Committee and the American College of Sports Medicine acknowledge caffeine's performance-enhancing effects, especially in endurance sports and high-intensity, short-duration activities. Doses between 3-6 mg/kg body weight taken about one hour before exercise are commonly used in studies and are considered effective and safe for most individuals. The evidence supporting caffeine's use in exercise contexts is robust, with numerous systematic reviews and meta-analyses confirming statistically significant improvements in a variety of exercise modalities.

Overall, the use of 1,3,7-Trimethylpurine-2,6-dione (caffeine) to support or enhance physical exercise is strongly backed by scientific evidence, earning it the highest rating for scientific validation in this context.

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