Evidence supporting the use of: Alpha-ketoisocaproic acid
For the health condition: Exercise

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Alpha-ketoisocaproic acid (KIC) is a keto acid derived from the metabolism of the branched-chain amino acid leucine. Its use in exercise and sports nutrition originates from its role as an intermediate in amino acid metabolism, with the hypothesis that supplementation could reduce muscle breakdown, decrease ammonia accumulation, and improve performance or recovery. Several studies have investigated KIC either alone or in combination with other supplements (such as HMB or glycine-arginine), often examining its effects on muscle soreness, strength, and exercise-induced fatigue.

However, the scientific evidence supporting its effectiveness is limited and somewhat inconsistent. Some small-scale trials and pilot studies suggest possible benefits in reducing muscle damage and improving recovery, but these effects are modest and not consistently replicated across studies. Most research uses multi-ingredient formulas, making it difficult to isolate the specific effect of KIC. Furthermore, systematic reviews and meta-analyses generally conclude that the evidence for KIC alone is weak, and more rigorous, larger-scale studies are needed.

In summary, while there is a plausible biochemical rationale and some preliminary research, the overall scientific validation for using alpha-ketoisocaproic acid to support exercise performance or recovery is limited, and the evidence base is rated as low to moderate in quality.

More about Alpha-ketoisocaproic acid
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Other health conditions supported by Alpha-ketoisocaproic acid

Athletic and Exercise Aids
Body Building
Exercise
Muscle Tone (lack of)
Wasting

Products containing Alpha-ketoisocaproic acid

We currently have no products on Vitabase that contain this ingredient.