Evidence supporting the use of: Arginine creatine
For the health condition: Exercise

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Arginine creatine is a combination of two well-known supplements: L-arginine and creatine. Both have been individually studied for their effects on exercise performance. Creatine is one of the most extensively researched supplements in sports nutrition, with strong evidence supporting its role in enhancing high-intensity exercise performance, increasing muscle mass, and improving strength and power output. Numerous randomized controlled trials and meta-analyses have confirmed creatine's efficacy, particularly in activities that require repeated short bursts of energy, such as weightlifting and sprinting.

L-arginine serves as a precursor to nitric oxide, a molecule that helps dilate blood vessels and potentially improves blood flow. Some studies have explored whether L-arginine supplementation can improve exercise capacity by enhancing oxygen and nutrient delivery to muscles. However, the evidence for L-arginine alone is mixed, with many studies showing minimal or no benefit for exercise performance in healthy individuals.

When combined as arginine creatine, some manufacturers suggest synergistic effects, potentially improving both energy production and blood flow. However, direct studies on the combination are limited. The scientific rationale is based on the individual roles of creatine and arginine, but there is less robust evidence specifically supporting the use of the combined form for exercise enhancement.

In summary, while creatine alone is strongly supported for exercise performance (evidence level 5), the combination with arginine (arginine creatine) has a moderate evidence base (level 3), mainly extrapolated from studies on the individual components rather than the combination itself.

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