Evidence supporting the use of: Arginine pyroglutamate
For the health condition: Exercise

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Synopsis

Source of validity: Scientific
Rating (out of 5): 1

Arginine pyroglutamate is a compound combining the amino acid L-arginine and pyroglutamic acid. L-arginine is well-studied for its role as a precursor to nitric oxide, which can promote vasodilation and potentially enhance blood flow during exercise. Some research supports the use of L-arginine alone for exercise performance, but the results are mixed and often show only modest benefits, primarily in untrained or older populations.

However, studies specifically on arginine pyroglutamate and its effects on exercise performance are extremely limited. A handful of small human trials and animal studies have explored its potential cognitive benefits due to enhanced blood flow, but robust evidence for athletic or exercise performance is lacking. Theoretically, the combination may improve bioavailability compared to L-arginine alone, but this has not been conclusively demonstrated in the context of exercise.

In summary, while there is a plausible mechanism and some extrapolation from L-arginine research, there is a significant lack of direct scientific evidence supporting the use of arginine pyroglutamate specifically for exercise enhancement. Its use is occasionally mentioned in sports nutrition, but it is not widely endorsed by authoritative guidelines or supported by high-quality clinical trials.

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Other health conditions supported by Arginine pyroglutamate

Exercise

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