Evidence supporting the use of: Creatine alpha-ketoglutarate
For the health condition: Exercise

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Creatine alpha-ketoglutarate (Creatine AKG) is a compound that combines creatine with alpha-ketoglutarate, a molecule involved in the Krebs cycle. The use of creatine itself for exercise performance, especially for increasing strength, power, and lean mass, is strongly supported by scientific evidence. However, the specific form—creatine alpha-ketoglutarate—has not been studied extensively in peer-reviewed human clinical trials. The rationale for combining creatine with alpha-ketoglutarate is based on the hypothesis that alpha-ketoglutarate may enhance creatine uptake or provide additional energy benefits via the Krebs cycle, but direct evidence for these synergistic effects in humans is lacking.

Most of the available scientific literature and systematic reviews focus on creatine monohydrate, with robust evidence supporting its efficacy for improving high-intensity exercise performance and muscle mass. For creatine AKG, the evidence is limited to small studies, animal models, or theoretical discussions. Thus, while its use is grounded in the well-established effects of creatine, the specific benefits of the alpha-ketoglutarate combination have not been validated with high-quality research. Therefore, Creatine AKG is used with the expectation of similar benefits to creatine monohydrate, but claims of superior or unique effects for exercise are not substantiated by current scientific evidence.

More about Creatine alpha-ketoglutarate
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Other health conditions supported by Creatine alpha-ketoglutarate

Athletic and Exercise Aids
Exercise
Wasting

Products containing Creatine alpha-ketoglutarate

We currently have no products on Vitabase that contain this ingredient.