Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Endo-peptidases, a class of proteolytic enzymes, are used as dietary supplements with the aim of enhancing recovery from exercise-induced muscle damage and supporting protein digestion. The scientific rationale for their use in exercise settings centers on their ability to hydrolyze peptide bonds in dietary and endogenous proteins, potentially aiding in faster muscle recovery and reduced soreness. Some small clinical trials and animal studies indicate that oral supplementation with proteolytic enzymes (such as bromelain, papain, or microbial endo-peptidases) may reduce markers of inflammation and subjective muscle soreness following intense exercise. Proposed mechanisms include the breakdown of inflammatory mediators and facilitation of protein turnover in damaged tissues.

However, the quality and quantity of evidence are limited. Most studies use mixtures of proteolytic enzymes rather than purified endo-peptidases, and results are variable. Meta-analyses suggest a modest benefit in reducing delayed onset muscle soreness (DOMS), but the effect size is small and the clinical significance is debated. Furthermore, the bioavailability of orally ingested enzymes is questionable, as many are likely degraded in the gastrointestinal tract before reaching systemic circulation. In summary, while there is some scientific basis and preliminary evidence supporting the use of endo-peptidases for exercise recovery, more rigorous, large-scale human trials are needed to establish efficacy and optimal dosing.

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