Relationship: Exercise and l-glycine

Evidence supporting the use of: L-glycine
For the health condition: Exercise

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

L-glycine is a non-essential amino acid that plays several roles in human physiology, including as a building block for proteins, a precursor for biosynthesis of key biological compounds (such as creatine and glutathione), and as an inhibitory neurotransmitter. Its use in supporting or treating exercise performance and recovery has some scientific basis, though the evidence is still emerging and not robust.

Research suggests glycine supplementation may help reduce inflammation and oxidative stress related to intense exercise, potentially improving recovery. For example, animal studies have demonstrated that glycine can mitigate muscle damage and oxidative markers following exhaustive exercise. A few small human studies indicate that glycine, often in combination with other amino acids, could lower markers of muscle damage and support immune function post-exercise. Additionally, glycine’s role as a precursor to creatine and glutathione may theoretically benefit exercise performance and recovery, as both compounds are known to support energy metabolism and cellular defense mechanisms in active muscles.

However, the direct evidence for glycine alone enhancing exercise performance, endurance, or muscle growth in humans is limited and not as strong as for other amino acids like leucine or creatine. Most available studies are small, preliminary, or use multi-ingredient formulas. Therefore, while there is some scientific rationale and emerging evidence, the overall strength of evidence supporting glycine specifically for exercise support is modest and warrants further research.

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Other ingredients used for Exercise

Acetyl L-carnitine
adenosine 5-triphosphate disodium (ATP)
ashwagandha
astaxanthin
beta-alanine
branched-chain amino acids
capsaicinoids
coenzyme Q10 (CoQ10)
colostrum
cordyceps
creatine monohydrate
endo-peptidase
fructose
ginseng
L-alanyl-L-glutamine
L-citrulline
L-glutamine
L-glycine
magnesium
omega-3 fatty acids
ornithine alpha-ketoglutarate
protease
protein
spirulina
succinic acid
vitamin B12
Zinc
capsicum
electrolytes blend (proprietary)
1,3,7-Trimethylpurine-2,6-dione
arginine alpha ketoglutarate
Alpha polylactate
arginine creatine
arachidonic acid
Alpha-ketoisocaproic acid
Arginine pyroglutamate
Alpha hydroxyisocaproic acid
Arginine silicate
beta-hydroxybutyrate
bovine protein
BCAA
chia seed
Creatyl-L-glutamine
D-Aspartic Acid
dextrose
Dipeptide
Ethyl-Alpha-Guanido-Methyl-Ethanoate
fatty acids
Glutamine
Growth factors
Higenamine
ketone salts
lysophosphatidic acid
Phosphatidic Acid

Other health conditions supported by L-glycine

Anxiety
Anxiety Disorders
Athletic and Exercise Aids
Autoimmune Disorders
Body Building
Cardiovascular Disease
Chemotherapy (reducing side effects)
Convalescence
Cuts
Depression
Diabetes
Energy (lack of)
Exercise
Fatigue
Free Radical Damage
Gastritis

Products containing L-glycine

Health Concerns

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Evidence supporting the use of: L-glycine
For the health condition: Exercise

Table of Contents

Synopsis

Other ingredients used for Exercise

Other health conditions supported by L-glycine

Products containing L-glycine

Health Concerns

Brands

Evidence supporting the use of: L-glycineFor the health condition: Exercise

Table of Contents

Synopsis

Other ingredients used for Exercise

Other health conditions supported by L-glycine

Products containing L-glycine

Evidence supporting the use of: L-glycine
For the health condition: Exercise