Evidence supporting the use of: Potassium alpha-ketoisocaproate
For the health condition: Exercise

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Potassium alpha-ketoisocaproate (KIC) is a metabolite of the branched-chain amino acid leucine and has been studied for its potential effects on exercise performance and recovery. Scientific interest in KIC has primarily focused on its role in reducing muscle breakdown and promoting muscle protein synthesis, theorizing that it may buffer ammonia accumulation during intense exercise and support the muscle's energy needs.

Some early studies (mainly from the 1980s and 1990s) suggested that supplementation with KIC, especially in combination with other compounds such as HMB (beta-hydroxy beta-methylbutyrate), could help reduce exercise-induced muscle damage and improve strength recovery. However, the evidence is inconsistent and limited by small sample sizes and methodological weaknesses. More recent meta-analyses and systematic reviews generally conclude that while HMB (often derived from KIC) has modest benefits for exercise recovery and muscle preservation, there is insufficient direct evidence to support significant ergogenic or recovery benefits from KIC alone.

Overall, while the use of potassium alpha-ketoisocaproate as an exercise supplement is grounded in scientific rationale and has some preliminary evidence, the quality and quantity of supporting studies are limited. Thus, the scientific validation for its effectiveness in improving exercise performance or recovery is weak, warranting a modest evidence rating.

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Other health conditions supported by Potassium alpha-ketoisocaproate

Body Building
Exercise

Products containing Potassium alpha-ketoisocaproate

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