Little ironweed (Vernonia cinerea) has been used in traditional medicine systems, particularly in parts of Asia, for various ailments, including as a remedy for eye problems such as conjunctivitis and eye irritation. The use is primarily rooted in folk and Ayurvedic practices, where decoctions or extracts from the plant are applied as eye washes or poultices. However, these uses are based on anecdotal evidence and traditional beliefs rather than robust scientific research. A review of the available scientific literature reveals little to no clinical research examining the efficacy or safety of Vernonia cinerea specifically for eye conditions. Some laboratory studies have investigated the plant’s general antioxidant and anti-inflammatory properties, which could, in theory, have a beneficial effect on eye health if inflammation or oxidative stress is involved. However, these studies do not directly address its application for eye diseases or provide clinical validation for traditional uses. In summary, while Little ironweed is traditionally used for eye problems in certain cultures, there is currently insufficient scientific evidence to support its effectiveness for these indications. The evidence base remains very weak (rated 1/5), relying almost entirely on historical and anecdotal accounts rather than on controlled scientific studies.