Evidence supporting the use of: Oligomeric proanthocyanidins
For the health condition: Eye Problems

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Oligomeric proanthocyanidins (OPCs), most notably extracted from grape seed and pine bark, have been researched for their antioxidant properties and potential benefits in supporting eye health. Scientific studies suggest that oxidative stress plays a significant role in the pathogenesis of various eye problems, including age-related macular degeneration (AMD), diabetic retinopathy, and cataracts. OPCs are potent antioxidants that may help neutralize free radicals in ocular tissues, potentially slowing disease progression. Some small-scale human trials and animal studies have demonstrated that OPC supplementation may improve microcirculation in the retina and protect retinal cells from oxidative damage. For example, a limited number of clinical studies indicate that OPCs can help reduce retinal capillary permeability and improve visual function in individuals with diabetic retinopathy. However, the overall quality and quantity of evidence remain modest: systematic reviews note that while there is biological plausibility and some promising results, large-scale, high-quality randomized controlled trials are lacking. Therefore, OPCs are regarded as a scientifically plausible adjunct for eye health, but currently, the evidence supporting their routine use for treating or preventing eye diseases remains preliminary. Further research is needed to confirm efficacy, optimal dosing, and long-term safety.

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