Evidence supporting the use of: 3,3'-dihydroxy-B-carotene-4,4'-dione
For the body system: Eyes

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

3,3'-Dihydroxy-β-carotene-4,4'-dione, also known as astaxanthin, is a naturally occurring carotenoid pigment found in microalgae, yeast, salmon, trout, krill, shrimp, and crayfish. There is a growing body of scientific evidence supporting its use for eye health. Astaxanthin is a potent antioxidant, significantly more powerful than other carotenoids like lutein or zeaxanthin, which are well known for their roles in ocular health. Several studies have demonstrated that astaxanthin can cross the blood-retinal barrier and accumulate in the retina, where it exerts protective effects against oxidative stress and inflammation—two major contributors to eye disorders such as age-related macular degeneration (AMD), diabetic retinopathy, and eye fatigue.

Clinical trials have shown that supplementation with astaxanthin can improve visual acuity, reduce eye strain and fatigue, and protect retinal cells from damage caused by light exposure and oxidative insults. For example, randomized controlled trials in humans have found improvements in accommodation (focus adjustment) and reductions in subjective symptoms of eye fatigue after prolonged screen use. Additionally, in vitro and animal studies have demonstrated the ability of astaxanthin to inhibit cell apoptosis and reduce inflammation in retinal tissues.

While further large-scale human studies are warranted, current scientific literature provides moderate to strong support for astaxanthin's beneficial effects on eye health, justifying its inclusion in supplements aimed at supporting the eyes and visual function.

More about 3,3'-dihydroxy-B-carotene-4,4'-dione
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Other ingredients that support Eyes

3,3'-dihydroxy-B-carotene-4,4'-dione
Acetyl L-carnitine
Alchornea
Algae
algal oil
Alpha-carotene
anchovies
anthocyanidins
anthocyanins
anthocyanosides
apricot
Aronia melanocarpa
astaxanthin
avocado
barbary matrimony vine
bee products
Beef liver
berry
beta-carotene
beta-zeacarotene
bilberry
bioflavonoids
black currant
blackberry
Blakeslea trispora
blueberry
broccoli
calamari oil
cantaloupe
capsanthin
Carnosine
carotene (unspecified)
carrot
Celosia
chickweed
Chinese Ligustrum berry
chrysanthemum
citicoline
cocklebur
cod liver oil
cornflower
Cornus
crocetin
crocin
Crypthecodinium
cryptoxanthin
currant
cyanidin
d-alpha tocopherol
DHA (docosahexaenoic acid)
docosahexaenoic Acid
Dunaliella
Dunaliella salina
egg
eicosapentaenoic acid
EPA (eicosapentaenoic acid)
ergothioneine
Eyebright
Fagopyrum
fat liver oil
fatty acids
fibroblast growth factor
fish
fish oil
flavoglycosides
flavonoids
flavonols
fruit
fruit and vegetable blend (proprietary)
Gac
gamma-carotene
ginkgo flavone glycoside
Glutathione
goji berry
gooseberry
Haematococcus pluvialis
haliotis
herbal blend (proprietary)
huckleberry
hyaluronic acid
Idebenone
kale
L-carnosine
L-taurine
Ligustrum
lipids
lutein
Lycium
marigold
Marine fat
Marine lipid
Melatonin
Mineral ascorbate
mixed carotenoids
Morus
Mulberry
N-Acetyl Carnosine
Oligomeric proanthocyanidins
omega-3 fatty acids
orange
Phaffia rhodozyma
pine bark
Polygonum
polyphenols
polyunsaturated fat
proanthocyanidins
procyanidol
pumpkin
Pycnogenol
riboflavin (vitamin B2)
rose
rue
rutin
saffron
Salmon Oil
Schizochytrium
Schizochytrium Oil
Spanish Needle
spinach
Tagetes
Taurine
Tea
trace minerals
Triphala
Troxerutin
vegetable and fruit blend (proprietary)
vitamin A
vitamin B
vitamin C
vitamin E
Xanthophyll
Zeaxanthin
Zinc

Other body systems supported by 3,3'-dihydroxy-B-carotene-4,4'-dione

Eyes
Immune System
Skin

Products containing 3,3'-dihydroxy-B-carotene-4,4'-dione

We currently have no products on Vitabase that contain this ingredient.