Evidence supporting the use of: Anthocyanidins (unspecified)
For the body system: Eyes

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Anthocyanidins are a class of flavonoids found in various fruits and vegetables, notably in berries, grapes, and red cabbage. Their use to support eye health is primarily justified by emerging scientific research, though much of it is preclinical or based on small human studies. Anthocyanidins, and their glycosylated counterparts anthocyanins, possess potent antioxidant properties, which are thought to protect ocular tissues from oxidative stress—a key factor in the development of age-related macular degeneration (AMD) and other retinal diseases.

Several animal and in vitro studies have shown that anthocyanidins can protect retinal cells from oxidative damage, inhibit inflammation, and improve microcirculation in ocular tissues. Human studies are more limited but include small clinical trials and observational studies. For example, bilberry extract (rich in anthocyanidins/anthocyanins) has been associated with a reduction in eye fatigue and improvement in night vision, though results are inconsistent and often limited by methodological weaknesses.

While there is a plausible biological rationale and some supporting evidence, robust clinical trials in humans are lacking. Therefore, anthocyanidins are considered to have moderate scientific support for eye health, mostly based on their antioxidant effects and promising but preliminary human studies.

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