Evidence supporting the use of: Bioflavonoid
For the body system: Eyes

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Bioflavonoids, also known as flavonoids, are a group of polyphenolic compounds found abundantly in fruits and vegetables, especially citrus fruits. Their use to support eye health is primarily based on their antioxidant and anti-inflammatory properties. Scientific studies have shown that oxidative stress and inflammation are key contributors to the development of various eye disorders, including age-related macular degeneration (AMD) and cataracts. Bioflavonoids, particularly compounds like quercetin, hesperidin, and rutin, have demonstrated the ability to scavenge free radicals and reduce inflammation in laboratory and some animal studies.

Some observational studies suggest that higher dietary intake of flavonoids is associated with a lower risk of certain eye diseases. For example, research has shown that individuals who consume diets rich in fruits and vegetables containing bioflavonoids may have a reduced risk of developing AMD. However, clinical trials directly examining the efficacy of bioflavonoid supplementation for eye health in humans are limited and have provided mixed results. The best-known clinical study for eye health, the AREDS and AREDS2 trials, did not specifically investigate bioflavonoids, focusing instead on other antioxidants.

In summary, there is scientific rationale and preliminary evidence supporting the potential role of bioflavonoids in promoting eye health, mostly due to their antioxidant effects. However, high-quality human clinical trials are lacking, and thus the evidence remains modest (rating: 2/5).

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