Vitamins are widely recognized for their role in supporting eye health, with significant scientific evidence backing the use of specific vitamins for this purpose. In particular, vitamins A, C, and E, along with certain B vitamins and carotenoids like lutein and zeaxanthin, have been studied extensively for their protective effects on vision and eye tissues. Vitamin A is crucial for maintaining the function of the retina and for preventing night blindness and xerophthalmia. The Age-Related Eye Disease Study (AREDS) and its follow-up (AREDS2), major clinical trials sponsored by the National Eye Institute, found that high-dose combinations of vitamins C and E, beta-carotene (a precursor to vitamin A), and the minerals zinc and copper can significantly reduce the risk of progression to advanced age-related macular degeneration (AMD).

Lutein and zeaxanthin, present in some vitamin blends, are carotenoids that accumulate in the retina and help filter harmful blue light, potentially reducing the risk of AMD and cataracts. Vitamin C also supports blood vessel health in the eyes and may lower the risk of cataract formation. Thus, there is substantial scientific validation for the use of vitamin blends (specifically those containing these vitamins and carotenoids) to support eye health, particularly in the context of age-related eye conditions. However, it is important to note that not all vitamin blends are formulated equally, and benefits depend on the specific components and dosages used.