Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Citicoline, also known as CDP-choline, has garnered scientific interest for its potential benefits in supporting eye health, particularly in the context of glaucoma and other optic neuropathies. Several clinical studies and reviews have investigated citicoline’s neuroprotective properties, noting its role in stabilizing cell membranes, enhancing neurotransmitter synthesis, and promoting neuronal repair mechanisms. In ophthalmology, research has shown that citicoline can improve visual function and slow the progression of visual field loss in patients with glaucoma, likely by supporting retinal ganglion cell function and optic nerve health. Delivery methods studied include oral, intramuscular, and topical (eye drop) formulations, with positive outcomes reported for all routes.

However, while initial studies are promising, most are small, short-term, or lack extensive replication. Systematic reviews and meta-analyses published in reputable journals note that citicoline appears safe and may provide benefit, but emphasize the need for larger, high-quality randomized controlled trials to confirm efficacy for glaucoma and other neurodegenerative eye conditions. Thus, while citicoline’s use in eye health is supported by preliminary scientific evidence, it is not yet considered a standard or universally accepted treatment in ophthalmology, and its benefit should be regarded as probable but not conclusively established.

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