Crocin, a carotenoid compound primarily found in saffron (Crocus sativus), has garnered scientific interest for its potential benefits in supporting ocular health. Multiple preclinical and clinical studies have investigated crocin's impact on various eye conditions, particularly age-related macular degeneration (AMD) and retinal degeneration. Research suggests that crocin exhibits potent antioxidant properties, which help mitigate oxidative stress—a key factor in the pathogenesis of many eye diseases.

Several animal studies have demonstrated crocin’s capacity to protect retinal cells from light-induced and oxidative damage. Human trials, though limited in number, have also reported promising outcomes. For example, a randomized, double-blind, placebo-controlled trial published in Evidence-Based Complementary and Alternative Medicine (2015) found that oral supplementation with crocin improved visual function in patients with early AMD. The proposed mechanisms include enhancement of retinal blood flow, reduction of apoptosis in photoreceptor cells, and inhibition of inflammatory pathways.

While more large-scale clinical trials are needed to confirm these findings and establish optimal dosing, the current body of evidence provides moderate to strong scientific support for crocin’s role in supporting eye health, especially in the context of degenerative retinal diseases.