Evidence supporting the use of: Cyanidin-3-glucoside
For the body system: Eyes

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Cyanidin-3-glucoside (C3G) is a type of anthocyanin, a class of plant pigments widely found in berries and other colorful fruits and vegetables. There is moderate scientific evidence supporting the role of C3G in supporting eye health, particularly regarding its antioxidant effects and potential to improve visual function. Several in vitro and animal studies have demonstrated that C3G can protect retinal cells against oxidative stress, which is implicated in age-related macular degeneration (AMD) and other retinal diseases. Some small human studies have shown that anthocyanin-rich extracts (including C3G) may improve night vision, visual acuity, and reduce eye fatigue, although the effects are generally mild and the studies often use mixed anthocyanin sources rather than purified C3G. A 2010 review ("Anthocyanins and Human Health: An Update") summarizes evidence suggesting that anthocyanins can support retinal health by scavenging free radicals and modulating inflammatory pathways in the eye. However, more robust randomized controlled trials are needed to confirm these effects specifically for C3G. Most current evidence comes from studies on bilberry or blackcurrant extracts, which contain significant amounts of C3G but are not exclusive sources. In summary, while there is promising preliminary evidence that Cyanidin-3-glucoside may support eye health through antioxidant and anti-inflammatory mechanisms, the overall quality and quantity of human studies are moderate. Thus, its use is scientifically plausible but not conclusively validated for eye health.

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