Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Eicosapentaenoic acid (EPA) is an omega-3 polyunsaturated fatty acid found predominantly in fish oils and is widely studied for its health effects, including on eye health. Scientific evidence supports the use of EPA, often in combination with docosahexaenoic acid (DHA), for certain eye conditions, most notably dry eye disease and age-related macular degeneration (AMD). Multiple randomized controlled trials and systematic reviews suggest that supplementation with omega-3 fatty acids can help improve symptoms of dry eye by enhancing tear production and reducing inflammation of the ocular surface. For AMD, the Age-Related Eye Disease Study 2 (AREDS2) evaluated EPA (with DHA) supplementation; while the study did not find a statistically significant reduction in progression to advanced AMD, other studies and meta-analyses suggest a possible protective effect, particularly when dietary intake of omega-3 is low. The anti-inflammatory properties of EPA are believed to play a key role in its ocular benefits, helping to reduce ocular surface inflammation and support retinal function. However, while the evidence is substantial, results are not uniformly positive across all studies, and the benefits may vary depending on baseline dietary intake and individual patient characteristics. In summary, the use of EPA to support eye health is supported by scientific research, particularly for dry eye symptoms, but more research is needed to clarify its role in preventing or treating other eye diseases.

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Other ingredients that support Eyes

Acetyl L-carnitine
algal oil
Alpha-carotene
anchovies
anthocyanins
apricot
astaxanthin
berry flavor
beta-carotene
bilberry
black currant
blackberry
blueberry
broccoli
calamari oil
carrot
citicoline
cryptoxanthin
d-alpha tocopherol
DHA (docosahexaenoic acid)
EPA (eicosapentaenoic acid)
fish oil
flavonols
fruit and vegetable blend (proprietary)
gooseberry
hyaluronic acid
hypromellose
kale
L-carnosine
L-taurine
lutein
mannitol
Marine lipid
Melatonin
mixed carotenoids
omega-3 fatty acids
orange
pine bark
pumpkin
riboflavin (vitamin B2)
rutin
saffron
spinach
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vegetable and fruit blend (proprietary)
vitamin A
vitamin B
vitamin C
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chickweed
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goji berry
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avocado
anthocyanidins
anthocyanosides
beta-zeacarotene
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bioflavonoids
bee products
barbary matrimony vine
crocin
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cod liver oil
cyanidin
cornflower
cantaloupe
Chinese Ligustrum berry
Cornus
carotene (unspecified)
crocetin
cocklebur
Crypthecodinium
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capsanthin
currant
Dunaliella salina
docosahexaenoic Acid
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egg
ergothioneine
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eicosapentaenoic acid
fruit
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procyanidol
proanthocyanidins
polyunsaturated fat
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rue
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Schizochytrium Oil
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Other body systems supported by eicosapentaenoic acid

Arteries
Blood
Brain
Capillaries
Circulatory System
Eyes
Heart
Immune System
Intestinal System
Joints
Lungs
Reproductive System
Skin

Products containing eicosapentaenoic acid

We currently have no products on Vitabase that contain this ingredient.