Evidence supporting the use of: Ergothioneine
For the body system: Eyes

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Ergothioneine is a naturally occurring amino acid derivative with antioxidant properties, found in foods such as mushrooms. Its role in eye health has been the focus of some emerging scientific interest. The rationale for its use in supporting the eyes centers on the fact that oxidative stress contributes to the development of various ocular diseases, notably cataracts and age-related macular degeneration (AMD). Ergothioneine is known to accumulate in tissues exposed to high oxidative stress, including the lens and retina, suggesting a protective effect.

Several in vitro and animal studies have shown that ergothioneine can scavenge reactive oxygen species and protect ocular cells from oxidative damage. For example, research has demonstrated that ergothioneine supplementation can reduce lens opacity in animal models, a proxy for cataract formation. However, human clinical studies directly examining ergothioneine supplementation for eye health are very limited or lacking. Most of the evidence comes from mechanistic studies or indirect epidemiological data linking dietary intake of ergothioneine-rich foods with lower risk of eye diseases.

In summary, while there is a plausible scientific basis and some preclinical evidence for ergothioneine’s role in protecting the eyes from oxidative damage, direct clinical validation in humans is limited at this time. Therefore, the scientific support for ergothioneine as an eye health supplement is still considered preliminary.

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