Evidence supporting the use of: Ethyl Esters (unspecified)
For the body system: Eyes

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Table of Contents

Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Ethyl esters, particularly ethyl esters of omega-3 fatty acids such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), are commonly used in dietary supplements. There is scientific evidence supporting the use of omega-3 fatty acid ethyl esters for eye health, particularly in the management of dry eye syndrome. Multiple randomized controlled trials and meta-analyses have shown that supplementation with omega-3 fatty acids can improve tear production and reduce symptoms of dry eye, likely due to their anti-inflammatory effects on the ocular surface and meibomian glands.

For example, a study published in the journal Cornea (2015) demonstrated significant improvement in dry eye symptoms in patients taking omega-3 ethyl esters compared to placebo. Similarly, the DREAM study (2018), a large multicenter trial, showed mixed results, but a subgroup analysis suggested some benefit in certain populations. The mechanism involves the incorporation of EPA and DHA into cell membranes, leading to altered production of lipid mediators that can decrease ocular surface inflammation.

It should be noted that while evidence supports the use of omega-3 ethyl esters for dry eye, there is less robust data for other eye conditions such as macular degeneration. The use of unspecified ethyl esters not derived from omega-3s is not supported for eye health. Therefore, the evidence rating is moderate and specific to omega-3 ethyl esters.

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Other body systems supported by Ethyl Esters (unspecified)

Arteries
Blood
Brain
Circulatory System
Eyes
Heart
Joints

Products containing Ethyl Esters (unspecified)

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