Evidence supporting the use of: Flavonoid glycosides
For the body system: Eyes

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Flavonoid glycosides are a class of plant-derived compounds that have been studied for their potential benefits in supporting eye health. The scientific rationale for their use centers on their antioxidant and vascular-protective properties. Flavonoid glycosides, such as those found in bilberry (Vaccinium myrtillus), Ginkgo biloba, and citrus fruits, can scavenge reactive oxygen species and help protect ocular tissues from oxidative stress—a key factor in the development of age-related macular degeneration (AMD) and diabetic retinopathy.

Several clinical and preclinical studies have indicated that flavonoid glycosides may improve capillary resistance and microcirculation in the retina, thus supporting visual function. For example, bilberry extract, rich in anthocyanin glycosides, has been associated with improved night vision and slowed progression of retinal diseases in some small-scale studies, though results are mixed and not universally conclusive. Ginkgo biloba extract, standardized to contain flavonoid glycosides, has shown potential for slowing the progression of normal tension glaucoma in some randomized controlled trials.

However, the overall quality of evidence is moderate. While laboratory and animal studies are promising, human data is limited and sometimes conflicting, leading to a cautious rating. Still, the biological plausibility and consistent findings regarding vascular and antioxidant benefits provide a reasonable scientific basis for the use of flavonoid glycosides to support eye health.

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