Evidence supporting the use of: Melatonin
For the body system: Eyes

Links: Go back one page, Tool main page, Ingredients list, Health conditions list, Body systems list

Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Melatonin is primarily known for its role in regulating sleep-wake cycles, but emerging scientific evidence suggests it may also support eye health. Melatonin is naturally present in the retina and other ocular tissues, where it appears to act as an antioxidant and modulate intraocular pressure. Several laboratory and animal studies have demonstrated that melatonin can protect retinal cells from oxidative stress and may help regulate physiological processes related to the circadian rhythm within the eye. Some small human studies have explored melatonin’s potential in conditions such as glaucoma, where it may help lower intraocular pressure, though results are preliminary and not yet conclusive for clinical recommendation. Furthermore, melatonin’s antioxidant properties suggest it could help mitigate damage from light exposure and aging in retinal tissues.

Despite these findings, the overall quality and quantity of human clinical trials are limited, and melatonin is not broadly recognized as a standard treatment or preventive agent for eye diseases. Most of the supporting evidence comes from experimental models rather than large-scale clinical trials. Therefore, while there is scientific interest and some supportive findings, the evidence base is not robust enough to warrant strong recommendations for melatonin’s use specifically for eye health at this time.

More about Melatonin
More about Eyes

Other ingredients that support Eyes

3,3'-dihydroxy-B-carotene-4,4'-dione
Acetyl L-carnitine
Alchornea
Algae
algal oil
Alpha-carotene
anchovies
anthocyanidins
anthocyanins
anthocyanosides
apricot
Aronia melanocarpa
astaxanthin
avocado
barbary matrimony vine
bee products
Beef liver
berry
beta-carotene
beta-zeacarotene
bilberry
bioflavonoids
black currant
blackberry
Blakeslea trispora
blueberry
broccoli
calamari oil
cantaloupe
capsanthin
Carnosine
carotene (unspecified)
carrot
Celosia
chickweed
Chinese Ligustrum berry
chrysanthemum
citicoline
cocklebur
cod liver oil
cornflower
Cornus
crocetin
crocin
Crypthecodinium
cryptoxanthin
currant
cyanidin
d-alpha tocopherol
DHA (docosahexaenoic acid)
docosahexaenoic Acid
Dunaliella
Dunaliella salina
egg
eicosapentaenoic acid
EPA (eicosapentaenoic acid)
ergothioneine
Eyebright
Fagopyrum
fat liver oil
fatty acids
fibroblast growth factor
fish
fish oil
flavoglycosides
flavonoids
flavonols
fruit
fruit and vegetable blend (proprietary)
Gac
gamma-carotene
ginkgo flavone glycoside
Glutathione
goji berry
gooseberry
Haematococcus pluvialis
haliotis
herbal blend (proprietary)
huckleberry
hyaluronic acid
Idebenone
kale
L-carnosine
L-taurine
Ligustrum
lipids
lutein
Lycium
marigold
Marine fat
Marine lipid
Melatonin
Mineral ascorbate
mixed carotenoids
Morus
Mulberry
N-Acetyl Carnosine
Oligomeric proanthocyanidins
omega-3 fatty acids
orange
Phaffia rhodozyma
pine bark
Polygonum
polyphenols
polyunsaturated fat
proanthocyanidins
procyanidol
pumpkin
Pycnogenol
riboflavin (vitamin B2)
rose
rue
rutin
saffron
Salmon Oil
Schizochytrium
Schizochytrium Oil
Spanish Needle
spinach
Tagetes
Taurine
Tea
trace minerals
Triphala
Troxerutin
vegetable and fruit blend (proprietary)
vitamin A
vitamin B
vitamin C
vitamin E
Xanthophyll
Zeaxanthin
Zinc