Evidence supporting the use of: Nerve growth factor
For the body system: Eyes
Synopsis
Source of validity: Scientific
Rating (out of 5): 4
Nerve Growth Factor (NGF) is a neurotrophin essential for the growth, maintenance, and survival of neurons. Its use in supporting the ocular system, particularly in treating certain eye disorders, is scientifically validated. Multiple studies have demonstrated the efficacy of NGF in promoting corneal healing and nerve regeneration. For example, recombinant human NGF (rhNGF) eye drops, branded as cenegermin (Oxervate), have received regulatory approval in both the European Union and the United States for the treatment of neurotrophic keratitis, a rare degenerative corneal disease. Clinical trials have shown that topical NGF can improve corneal healing rates and restore sensitivity in affected patients. The mechanism underlying NGF’s effectiveness in the eye involves its ability to stimulate the regeneration of corneal nerves and epithelial cells, leading to improved ocular surface health and function. Beyond neurotrophic keratitis, research is ongoing regarding NGF’s potential in treating other ocular conditions such as glaucoma, retinitis pigmentosa, and optic neuropathies, though these uses remain experimental. In summary, the use of NGF for supporting the eye, particularly in the context of corneal nerve damage and healing, is grounded in robust scientific evidence, with regulatory approvals underscoring its clinical utility for specific ophthalmic indications.
Other ingredients that support Eyes
Acetyl L-carnitinealgal oil
alpha-carotene
anchovies
anthocyanins
apricot
astaxanthin
berry flavor
beta-carotene
bilberry
black currant
blackberry
blueberry
broccoli
calamari oil
carrot
citicoline
cryptoxanthin
d-alpha tocopherol
DHA (docosahexaeonic acid)
EPA (eicosapentaenoic acid)
fish oil
flavonols
fruit and vegetable blend (proprietary)
gooseberry
hyaluronic acid
hypromellose
kale
L-carnosine
L-taurine
lutein
mackerel
mannitol
marine lipid
melatonin
mixed carotenoids
omega-3 fatty acids
orange
pine bark
pumpkin
riboflavin (vitamin B2)
rutin
saffron
sardines
shrimp
spinach
tomato
triphala
vegetable and fruit blend (proprietary)
vitamin A
vitamin B
vitamin C
vitamin E
water
mulberry
zeaxanthin
zinc
chickweed
morus
chrysanthemum
haliotis
polyphenols
trace minerals
goji berry
herbal blend (proprietary)
Algae
3,3'-dihydroxy-B-carotene-4,4'-dione
Aronia melanocarpa
Alchornea
Avocado
anthocyanidins
anthocyanosides
beta-zeacarotene
Beef liver
Blakeslea trispora
berry
Bioflavonoids
Bee products
Barbary matrimony vine
Crocin
Carnosine
Cod Liver Oil
Cyanidin
Cornflower
Cantaloupe
Chinese Ligustrum berry
Cornus
Carotene (unspecified)
Crocetin
Cocklebur
Crypthecodinium
Celosia
Capsanthin
Currant
Dunaliella salina
Docosahexaenoic Acid
Dunaliella
Egg
Ergothioneine
Eyebright
Eicosapentaenoic Acid
Fruit
Flavonoids
Fat liver oil
Fish
Fatty acids
Fagopyrum
Flavoglycosides
fibroblast growth factor
Gac
Ginkgo Flavone Glycoside
Glutathione
Gamma-carotene
Haematococcus pluvialis
Huckleberry
Idebenone
Lycium
Ligustrum
Lipids
Mineral ascorbate
Marine fat
Marigold
N-Acetyl Carnosine
Oligomeric proanthocyanidins
Phaffia rhodozyma
Procyanidol
Proanthocyanidins
Polyunsaturated Fat
Pycnogenol
Polygonum
Rue
Rose
Schizochytrium Oil
Spanish Needle
Schizochytrium
Squid
Salmon Oil
Squash
Tea
Troxerutin
Taurine
Tagetes
Xanthophyll