Evidence supporting the use of: Proanthocyanidin (unspecified)
For the body system: Eyes

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Proanthocyanidins, a class of polyphenolic compounds found abundantly in foods like grapes, berries, and cocoa, are sometimes used as dietary supplements purported to support eye health. Scientific interest in proanthocyanidins for the eyes centers around their antioxidant properties, which could protect ocular tissues from oxidative stress—a factor implicated in conditions such as age-related macular degeneration (AMD) and cataracts. Some in vitro and animal studies suggest that proanthocyanidins can reduce oxidative damage to retinal cells and may improve microcirculation in the eye, potentially benefiting retinal health.

However, direct clinical evidence in humans is limited. A few small-scale clinical studies have investigated grape seed extract (rich in proanthocyanidins) for its effects on visual function and eye fatigue, but results are preliminary and not sufficiently robust to draw firm conclusions. There is some support for the use of proanthocyanidins in diabetic retinopathy due to their effects on vascular health, but again, clinical trials are limited in size and scope. Overall, while the antioxidant rationale is plausible and supported by preclinical research, high-quality human studies are lacking, resulting in a modest evidence rating for this use.

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