Evidence supporting the use of: Vitamin E (mixed alpha-tocopherol)
For the body system: Eyes

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Vitamin E, particularly in the form of mixed alpha-tocopherols, has been investigated for its potential role in supporting eye health, primarily due to its antioxidant properties. The scientific interest largely stems from the role oxidative stress plays in the development of age-related eye diseases such as age-related macular degeneration (AMD) and cataracts. The Age-Related Eye Disease Study (AREDS) and its follow-up, AREDS2, were major randomized controlled trials that evaluated the effect of a combination of antioxidants (including vitamin E at 400 IU/day) and zinc on the progression of AMD. The results indicated that this combination slowed the progression of intermediate to advanced AMD in individuals at high risk, but vitamin E alone has not been conclusively shown to provide benefit.

Other studies on vitamin E supplementation alone have produced mixed results, with some epidemiological data suggesting a possible protective effect against cataracts and AMD, while randomized controlled trials have generally failed to show a significant benefit of vitamin E by itself. Overall, vitamin E is recognized as a supportive component in antioxidant formulas for eye health, but the evidence for its use as a standalone intervention is limited. There is scientific rationale for its inclusion as part of a combination therapy, but not strong validation for its solo use. Thus, the evidence is moderate, with a rating of 3 out of 5.

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