Evidence supporting the use of: Vitamin E (tocofersolan)
For the body system: Eyes

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Table of Contents

Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Vitamin E (including its water-soluble form, tocofersolan or tocophersolan) is used to support eye health, primarily for its antioxidant properties. The rationale is that oxidative stress contributes to the development of age-related eye diseases, particularly age-related macular degeneration (AMD) and cataracts. The most significant scientific evaluation comes from the Age-Related Eye Disease Study (AREDS and AREDS2), large randomized controlled trials sponsored by the National Eye Institute. The original AREDS formulation included vitamin E (400 IU), vitamin C, beta-carotene, zinc, and copper, and demonstrated a reduction in the risk of progression to advanced AMD in people at high risk. However, vitamin E’s role specifically, as opposed to the combination, is less clear, as subsequent studies have not shown conclusive benefit for vitamin E alone in preventing or slowing AMD or cataracts.

Tocofersolan is sometimes preferred in clinical settings (e.g., pediatrics, malabsorption disorders) because it is water-soluble and better absorbed in individuals with fat absorption issues. However, in the context of eye health, its use is based on the same antioxidant rationale as standard vitamin E. Overall, while antioxidant supplementation (including vitamin E) is scientifically validated as part of a combination for certain high-risk groups, the direct evidence for vitamin E alone (including tocofersolan) in supporting general eye health or preventing disease is moderate and not definitive.

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Other body systems supported by Vitamin E (tocofersolan)

Brain
Circulatory System
Eyes
Heart
Immune System
Liver
Male Reproductive System
Muscles
Skin

Products containing Vitamin E (tocofersolan)

We currently have no products on Vitabase that contain this ingredient.