Ligustrazin, also known as tetramethylpyrazine, is an active compound extracted from the traditional Chinese medicinal herb Ligusticum chuanxiong (Chuanxiong). In Traditional Chinese Medicine (TCM), Ligustrazin is commonly used to promote blood circulation and dispel blood stasis, and it is sometimes included in formulations aimed at treating ocular conditions characterized by redness or itching, which are thought to result from "wind-heat" or "blood stasis" patterns. The traditional rationale is that improving blood flow may alleviate discomfort in the eyes. However, there is minimal direct scientific evidence or high-quality clinical trials supporting the effectiveness of Ligustrazin for specifically treating red or itching eyes. Most research on Ligustrazin focuses on its cardiovascular, neuroprotective, and anti-inflammatory effects in other contexts. As such, its use for ocular irritation is primarily rooted in traditional practice rather than validated by rigorous scientific studies. The overall quality and amount of supporting evidence for this use is low, warranting a rating of 1 on the evidence scale.