Evidence supporting the use of: Mixed carotenoids
For the health condition: Eyesight (poor)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Carotenoids—particularly lutein, zeaxanthin, and beta-carotene—are natural pigments found in many fruits and vegetables that play an important role in eye health. Scientific evidence supports the use of mixed carotenoids to support and help prevent poor eyesight, especially age-related macular degeneration (AMD) and cataracts. Lutein and zeaxanthin are concentrated in the macula of the eye, where they filter harmful blue light and act as antioxidants, protecting retinal cells from oxidative damage. Several large-scale observational studies and randomized controlled trials, such as the Age-Related Eye Disease Study 2 (AREDS2), have found that supplementation with these carotenoids can slow the progression of AMD in individuals at risk. The AREDS2 formula specifically includes lutein and zeaxanthin, replacing beta-carotene due to lung cancer risk in smokers, and demonstrated a modest but significant reduction in risk of advanced AMD progression. Beta-carotene, a precursor to vitamin A, is critical for normal vision and prevents night blindness, although excessive supplementation is not recommended for everyone. The evidence for carotenoids in preventing cataracts is less robust but still supportive, with some studies showing reduced risk. While the greatest benefits are seen in individuals with existing risk factors for eye disease, the overall scientific consensus is that mixed carotenoids can help support eye health through their antioxidant and protective effects.

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