Evidence supporting the use of: Amino Acid Blend/Complex
For the health condition: Failure to Thrive

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Amino acid blends or complexes are used in the management of Failure to Thrive (FTT), particularly when the underlying cause is related to protein-energy malnutrition, malabsorption syndromes, or metabolic disorders that impair the body's ability to synthesize or utilize amino acids. FTT often presents in infants, children, or adults who are unable to achieve expected growth or weight gain. Amino acids are the building blocks of proteins, which are essential for growth, tissue repair, and immune function. Supplementation with balanced amino acid mixtures can help to provide easily absorbable protein precursors, especially in patients who cannot tolerate whole proteins or whose digestive function is compromised.

Scientific studies have demonstrated that specialized amino acid-based formulas support weight gain, linear growth, and nutritional status in infants and children with FTT related to gastrointestinal disorders (such as short bowel syndrome, severe food allergies, or inflammatory bowel disease) and certain inborn errors of metabolism. For example, a 2013 review in JPGN (Journal of Pediatric Gastroenterology and Nutrition) describes how amino acid-based formulas are effective in promoting catch-up growth in children with severe cow's milk protein allergy or multiple food allergies who fail to thrive. These formulas are also used in pediatric and adult clinical nutrition (e.g., parenteral nutrition) when standard protein sources are contraindicated.

While not universally required for all cases of FTT, the use of amino acid blends is scientifically validated in specific clinical contexts where protein digestion or absorption is impaired, earning a relatively high evidence rating.

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