Evidence supporting the use of: Blueberry (unspecified)
For the health condition: Fat Metabolism (poor)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Blueberry (Vaccinium spp.) is sometimes investigated for its potential effects on fat metabolism, largely due to its high polyphenol and anthocyanin content. Several preclinical (animal and in vitro) studies have suggested that blueberry extracts may influence fat metabolism by modulating lipid accumulation, enhancing mitochondrial function, and altering the expression of genes involved in fatty acid oxidation and adipogenesis. For example, some rodent studies have shown that supplementation with blueberry or its extracts can reduce body fat gain and improve lipid profiles under high-fat diet conditions. Mechanistically, these effects are often attributed to the antioxidant and anti-inflammatory properties of blueberry constituents, which may help regulate metabolic processes related to fat storage and breakdown.

However, evidence in humans remains limited and inconsistent. Few clinical trials have directly assessed blueberry supplementation for improving fat metabolism or treating metabolic disorders related to poor fat metabolism. The existing human studies are small, short-term, or focus on related endpoints like insulin sensitivity or markers of oxidative stress rather than direct measures of fat metabolism. As such, while there is a plausible biological rationale and some supportive animal data, robust clinical validation is lacking. Thus, the use of blueberry for supporting fat metabolism is scientifically plausible but not well established, justifying an evidence rating of 2 out of 5.

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