Evidence supporting the use of: Cardarine
For the health condition: Fat Metabolism (poor)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Cardarine (also known as GW501516) is a peroxisome proliferator-activated receptor delta (PPARδ) agonist developed in the 1990s. Its primary mechanism of action is the modulation of genes involved in fatty acid metabolism, particularly in skeletal muscle and liver. Preclinical studies in animals have demonstrated that Cardarine increases the expression of genes responsible for fatty acid oxidation, leading to enhanced fat burning and reduced fat mass. These effects have been replicated in several rodent models, showing improved lipid profiles, increased endurance, and resistance to diet-induced obesity.

However, human data are limited. A few small-scale clinical trials have shown that Cardarine can improve lipid profiles by lowering triglycerides and increasing HDL cholesterol, but robust evidence for significant fat loss or direct clinical benefit in humans is lacking. Additionally, Cardarine's development was halted due to concerns about potential carcinogenicity observed in long-term animal studies, raising significant safety issues that preclude its medical approval.

Despite some promising preclinical data supporting its role in fat metabolism, the lack of large, well-controlled human studies and safety concerns limit the strength of the evidence. Therefore, while Cardarine is widely used off-label among athletes and bodybuilders for its purported fat-burning effects, its use for supporting or treating poor fat metabolism is not currently justified by strong clinical evidence.

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Products containing cardarine

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