Evidence supporting the use of: Coleus forskohlii
For the health condition: Fat Metabolism (poor)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Coleus forskohlii is an herb traditionally used in Ayurvedic medicine, but its more recent popularity as a supplement is largely due to the presence of forskolin, a bioactive compound. Forskolin is thought to support fat metabolism and weight management primarily by stimulating the enzyme adenylate cyclase, which increases levels of cyclic AMP (cAMP) in cells. Elevated cAMP has been linked to increased lipolysis (the breakdown of fat) in some laboratory studies.

Several small human clinical trials have evaluated the effects of Coleus forskohlii extract or forskolin on body composition. Some studies suggest a modest reduction in body fat percentage and fat mass, particularly in overweight and obese men, though the effects are less consistent in women. For example, a 2005 study in males found a significant decrease in body fat percentage with supplementation, but another study in women did not find significant changes in weight loss compared to placebo. The number of studies is limited, the sample sizes are small, and some lack rigorous controls.

Overall, while there is some preliminary scientific evidence suggesting a potential benefit of Coleus forskohlii for supporting fat metabolism, the quality and quantity of the evidence is not strong. More large, well-controlled studies are needed to confirm these effects. As such, the evidence rating is 2 out of 5, indicating limited scientific support at this time.

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