Evidence supporting the use of: Gymnemagenin
For the health condition: Fat Metabolism (poor)
Synopsis
Source of validity: Scientific
Rating (out of 5): 2
Gymnemagenin is a principal bioactive compound found in Gymnema sylvestre, a plant traditionally used in Ayurvedic medicine for diabetes and metabolic conditions. Recent scientific studies have begun to explore its specific effects on fat metabolism, though evidence is still limited and primarily preclinical. A few in vitro and animal studies suggest that gymnemagenin may regulate lipid metabolism by modulating the expression of genes involved in adipogenesis and lipolysis. For example, a 2018 study by Pandey et al. (Scientific Reports) demonstrated that gymnemagenin upregulated genes associated with fat breakdown (such as PPARγ, C/EBPα, and adiponectin) in 3T3-L1 adipocytes. Other studies have indicated that gymnemagenin may suppress the accumulation of triglycerides and reduce lipid absorption in animal models. However, clinical trials in humans specifically investigating gymnemagenin’s direct impact on fat metabolism are lacking. Most human studies have focused on Gymnema sylvestre extracts rather than isolated gymnemagenin, and the results are not always consistent. In summary, while there is some scientific evidence suggesting a mechanism by which gymnemagenin could support fat metabolism, this evidence is preliminary and primarily based on cell and animal models, not robust clinical data. Therefore, its use for poor fat metabolism is scientifically plausible but not yet well-validated.
Other ingredients used for Fat Metabolism (poor)
7-Keto-DHEAAcetyl L-carnitine
alpha-linolenic acid (ALA)
anchovies
artichoke
barberry
biotin
canola oil
capsaicinoids
choline
cinnamon
Coleus forskohlii
conjugated linoleic acid (CLA)
turmeric
dandelion
epigallocatechin gallate (EGCG)
fenugreek
flavonols
forskohlii root
garcinia
ginger
glucomannan
guggul
hesperetin
hydroxycitric acid
kelp
l-carnitine
lecithin
linoleic acid (LA)
lipase
medium chain triglycerides (MCT)
Milk thistle
omega-3 fatty acids
omega-7 fatty acids
palmitate
pantethine
phospholipids
black ginger
vitamin B
Zinc
bile salt
polyphenols
AMP-activated protein kinase (AMPK)
3-desoxy-7-KETO-DHEA
apple cider vinegar
avocado
Alpha methyl tetradecylthioacetic acid
beta-hydroxybutyrate
Berberis (unspecified)
chia seed
capric acid
cardarine
carqueja
capsinoids
coconut oil
coriander
capsaicin
capsiate
cha de bugre
diacylglycerol
dihydrocapsiate
evodiamine
ephedrine
flavanones
fucoxanthin
forskolin
grains of paradise
gymnemic acids
Higenamine
isomaltulose
lipstatin
Legume protein
macadamia
Monounsaturated fat
oolong tea
Oleoylethanolamide
phaseolamin
Palatinose
Perperine
Pinolenic acid
Rauwolscine
robusta coffee
Synephrine
Tetradecylthioacetic acid
Thylakoid
Ursolic Acid
Wakame
Walnut
Yohimbine
Other health conditions supported by Gymnemagenin
Cholesterol (high)Diabetes
Fat Metabolism (poor)
Sugar Cravings
Weight Loss