Evidence supporting the use of: Gymnemagenin
For the health condition: Fat Metabolism (poor)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Gymnemagenin is a principal bioactive compound found in Gymnema sylvestre, a plant traditionally used in Ayurvedic medicine for diabetes and metabolic conditions. Recent scientific studies have begun to explore its specific effects on fat metabolism, though evidence is still limited and primarily preclinical. A few in vitro and animal studies suggest that gymnemagenin may regulate lipid metabolism by modulating the expression of genes involved in adipogenesis and lipolysis. For example, a 2018 study by Pandey et al. (Scientific Reports) demonstrated that gymnemagenin upregulated genes associated with fat breakdown (such as PPARγ, C/EBPα, and adiponectin) in 3T3-L1 adipocytes. Other studies have indicated that gymnemagenin may suppress the accumulation of triglycerides and reduce lipid absorption in animal models. However, clinical trials in humans specifically investigating gymnemagenin’s direct impact on fat metabolism are lacking. Most human studies have focused on Gymnema sylvestre extracts rather than isolated gymnemagenin, and the results are not always consistent. In summary, while there is some scientific evidence suggesting a mechanism by which gymnemagenin could support fat metabolism, this evidence is preliminary and primarily based on cell and animal models, not robust clinical data. Therefore, its use for poor fat metabolism is scientifically plausible but not yet well-validated.

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Other health conditions supported by Gymnemagenin

Cholesterol (high)
Diabetes
Fat Metabolism (poor)
Sugar Cravings
Weight Loss

Products containing Gymnemagenin

We currently have no products on Vitabase that contain this ingredient.