Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Hesperetin is a flavonoid derived from citrus fruits, and there is emerging scientific evidence suggesting its potential role in supporting fat metabolism. Preclinical studies, mainly in animal models and in vitro, have shown that hesperetin can modulate lipid metabolism through various mechanisms. For example, hesperetin has been reported to activate AMP-activated protein kinase (AMPK) and peroxisome proliferator-activated receptors (PPARs), both of which are key regulators of fatty acid oxidation and lipid homeostasis. Some studies have demonstrated that hesperetin can decrease lipogenesis and enhance fatty acid oxidation, resulting in reduced accumulation of body fat in high-fat diet-induced obese mice. Additionally, hesperetin has shown an ability to reduce serum triglycerides and cholesterol levels in animal models.

However, direct clinical evidence in humans is limited. Most of the supportive data comes from cell culture and animal studies, with few human trials directly evaluating hesperetin’s effects on fat metabolism or body composition. While hesperetin is being investigated for potential benefits in metabolic syndrome, obesity, and related disorders, the current evidence does not robustly support its use as a treatment for poor fat metabolism in humans. Thus, the rationale for its use is based on promising but preliminary scientific findings, and more rigorous clinical research is needed to firmly establish efficacy and safety for this indication.

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