Evidence supporting the use of: Higenamine
For the health condition: Fat Metabolism (poor)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Higenamine is a plant-derived alkaloid found in several traditional medicinal herbs, such as Nandina domestica and Aconitum species. In recent years, higenamine has attracted attention as a potential agent for supporting fat metabolism, particularly in the context of weight loss supplements. The scientific rationale for its use is primarily based on its action as a beta-adrenergic receptor agonist, similar to compounds like ephedrine and synephrine. By stimulating beta-adrenergic receptors, higenamine may increase lipolysis—the breakdown of fat stores—and promote energy expenditure. However, evidence supporting higenamine’s efficacy for fat metabolism in humans is limited. Most studies are preclinical, conducted in vitro or in animal models, where higenamine has been shown to increase heart rate, stimulate lipolysis, and enhance thermogenesis. Only a small number of human studies exist; these tend to be short-term, small-scale, and often focus on cardiovascular effects rather than direct fat loss outcomes. Some data suggest a modest acute increase in energy expenditure, but there is no robust evidence demonstrating significant or sustained fat loss in humans. In summary, higenamine’s use for supporting fat metabolism is scientifically plausible but not strongly validated in clinical research. The evidence base is weak, with a lack of high-quality human trials, hence a low evidence rating.

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Products containing Higenamine

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