Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Lipase is an enzyme that catalyzes the breakdown of dietary fats into smaller molecules, facilitating their absorption in the digestive tract. Its use to support or treat poor fat metabolism is primarily justified by scientific evidence, particularly in the context of conditions where endogenous lipase production is deficient. The most notable application of supplemental lipase is in the management of exocrine pancreatic insufficiency (EPI), a condition in which the pancreas does not secrete enough digestive enzymes, including lipase, leading to fat malabsorption, steatorrhea (fatty stools), and nutritional deficiencies. Clinical guidelines recommend pancreatic enzyme replacement therapy (PERT), which includes lipase, as the standard of care for EPI arising from chronic pancreatitis, cystic fibrosis, or pancreatic surgery. Randomized controlled trials and meta-analyses have shown that PERT improves fat absorption and nutritional status in affected patients.

However, outside of these medical indications, the evidence for using lipase supplements to support "poor fat metabolism" in the general population is weaker. Routine supplementation in individuals without diagnosed enzyme insufficiency has not been shown to provide significant health benefits, as healthy individuals typically produce adequate endogenous lipase. Therefore, while there is strong scientific support for lipase use in specific digestive disorders, the evidence for broader use in otherwise healthy individuals with subjective complaints of "poor fat metabolism" is limited. The overall evidence rating is 3 out of 5, reflecting solid support in specific clinical contexts but limited justification for general use.

More about lipase
More about Fat Metabolism (poor)

Other ingredients used for Fat Metabolism (poor)

Other health conditions supported by lipase

Products containing lipase

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Pure Encapsulations Digestion GB
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Pure Encapsulations Digestive Enzyme
Pure Encapsulations Digestive Enzymes Ultra
Pure Encapsulations Digestive Enzymes Ultra
Pure Encapsulations Digestive Enzymes Ultra with Betaine HCl
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Designs For Health Digestzymes™
Designs For Health Digestzymes™
Designs For Health Digestzymes™
Douglas Laboratories GI Digest
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Pure Encapsulations Heartburn Essentials
Vitabase Life's Essentials Plus
Integrative Therapeutics Nutrivitamin No-Iron
Designs For Health PaleoGreens®
Designs For Health PaleoGreens®
Designs For Health PaleoReds®
Pure Encapsulations Pancreatic Enzyme
Pure Encapsulations Pancreatic Enzyme
Pure Encapsulations Pancreatic VegEnzymes
Integrative Therapeutics Panplex 2-Phase
Metagenics PhytoGanix® Tropical Fruit
Designs For Health Plant Enzyme Digestive Formula
Integrative Therapeutics Similase
Integrative Therapeutics Similase
Integrative Therapeutics Similase BV
Integrative Therapeutics Similase GFCF
Integrative Therapeutics Similase-Lipo
Integrative Therapeutics Similase Sensitive Stomach
Integrative Therapeutics Similase Sensitive Stomach
Metagenics SpectraZyme® Complete
Metagenics SpectraZyme Complete
Metagenics SpectraZyme Pan 9x
Metagenics SpectraZyme Pan 9x
Metagenics SpectraZyme Pan 9x ES
Vitabase SuperZymes
Vitabase Ultra Dairy Support
Vitabase Ultra Veggie Enzymes