Evidence supporting the use of: Thylakoid
For the health condition: Fat Metabolism (poor)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Thylakoids—membrane-bound compartments found in chloroplasts (notably from spinach)—have been studied for their potential role in supporting fat metabolism and weight management. Several human clinical trials have shown that dietary supplementation with isolated thylakoids can modulate appetite, reduce hunger, and promote satiety, which may indirectly support fat metabolism by reducing caloric intake. The mechanism is thought to involve delayed fat digestion and absorption in the gut, leading to increased levels of satiety hormones such as cholecystokinin (CCK) and glucagon-like peptide-1 (GLP-1). A series of randomized controlled trials, primarily from Swedish research groups, have reported reductions in body fat and improvements in lipid profiles in overweight participants consuming thylakoid-enriched foods compared to controls. However, the evidence base remains relatively small, with limited studies outside specific populations, and most research has focused on appetite regulation and weight loss rather than direct effects on fat metabolism at the cellular or enzymatic level. Overall, while preliminary findings are promising and suggest a physiological basis for thylakoid supplementation in the context of poor fat metabolism, large-scale, long-term studies are needed to confirm these effects and clarify mechanisms.

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